The Effect of Age on The Number of Oocytes, Mature Oocytes, Fertilization, Embryo Quality, and Pregnancy in Women Undergoing in Vitro Fertilization at WIN IVF Clinic, RSIA Puri Bunda Hospital from 2019 to 2021

Abstract

Background: Infertility is a global issue affecting about 10-15% of reproductive-age couples, including approximately 6 million women in Indonesia struggling to conceive. In vitro fertilization (IVF) has become a primary method for addressing infertility, with the success of this procedure depending on the quantity and quality of both eggs and embryos produced.

Objective: This study aims to analyze the effect of women’s age on the number of eggs, mature eggs, fertilization, embryo quality, and pregnancy outcomes in the IVF program at WIN IVF Clinic RSIA Puri Bunda, Denpasar, during the period of 2019-2021.

Methods: This retrospective study used total sampling of IVF patient medical records, involving 402 patients grouped by age: ≤30, 31-35, 36-40, and >40 years.

Results: The findings indicate that age significantly impacts the number of eggs, mature eggs, fertilization, and embryo quality. The age group ≤35 years showed optimal outcomes in terms of egg count, mature eggs, fertilization, and high-quality embryos, while a significant decline was observed in those over 35 years (p<0.005). The highest pregnancy success rate was in the ≤30-year age group (41.8%) and dropped significantly in the >40-year age group (22.6%).

Conclusion: Female age is a crucial factor influencing IVF success. Women aged ≤35 have a higher chance of producing mature eggs, high-quality embryos, and achieving pregnancy. Therefore, specific strategies are needed to address infertility in older women to improve IVF success rates.