Correlation Between Glomerular Filtration Rate and Serum Uric Acid/Creatinine Ratio in Pre-dialysis Chronic Kidney Disease Patients at Ngoerah Hospital Denpasar

Abstract

Chronic kidney disease (CKD) is a structural and functional kidney abnormalities for over three months. Glomerular filtration rate (GFR) is an index to measure overall kidney function. Decreased renal excretory function leads to elevated serum uric acid and serum creatinine levels. The serum uric acid/creatinine ratio is recently recognized as an indicator of kidney function deterioration. The purpose of this study to determine the correlation between GFR and serum uric acid/creatinine ratio in pre-dialysis CKD patients at Ngoerah Hospital Denpasar. A cross-sectional analytical observational study was performed on 50 pre-dialysis CKD patients at Ngoerah Hospital Denpasar from 2022 to 2023, based on inclusion and exclusion criteria. The correlation between GFR and serum uric acid/creatinine ratio was assessed using Spearman's correlation test. The study participants were mostly male (68%), with a median age of 60.5 (21-79) years, and mostly in the stage G5 (74%). The median value of GFR was 16.85 (2.46-55.66) mL/min/1.73m² and the median value serum uric acid/creatinine ratio was 2.29 (0.39-7.49) mg/dL. The results of the correlation analysis between the GFR and serum uric acid/creatinine ratio was found r = 0.832 (p = 0.000). This study conclude there was strong and significant positive correlation between GFR and serum uric acid/creatinine ratio.