EFFECTS OF ETHANOL EXTRACT OF PADANG TARO LEAVES (COLOCASIA GIGANTEA) ON THE WEIGHT AND MUSCLE THICKNESS OF MALNOURISHED MODEL MICE

Abstract

Malnutrition can cause impaired growth and muscle mass. Talas Padang (Colocasia gigantea) is one of the sources of natural ingredients with nutritional content. This study aims to analyze the effect of various doses of administration ethanol leaf extract of Talas Padang (ELETP) on the weight and thickness of skeletal muscle (soleus) in malnourished rat. Pure experimental research with Post-test Only Control Group design using 25 malnourished rat (Wistar strain). ELETP is obtained macerated using 96% ethanol. Treatment in 5 groups (n=5), K1: normal 56-day diet; K2: low-protein diet (LPD) 14 days + normal 42-day diet; K3, K4 and K5: 14-day LPD + normal diet and ELETP doses of 100, 200, 400/kgBB for 42 days. The soleus muscle is obtained by dissection in the posterior aspect of the mouse leg to measure weight and thickness. Muscle weight data were analyzed using Anova's one-way test and muscle thickness using the Wallis Kruskal test. The results showed average (gr) of muscle weight K3 (0.246 ± 0.087) > K5 (0.236 ± 0.098) > K4 (0.215 ± 0.092) > K1 (0.188 ± 0.060) > K2 (0.127 ± 0.025) and muscle thickness (mm) K4 (1 (1-1) ) > K1, K3, K5 (1 (0,00-1) ) > K2 (0,00 (0,00-1) ). This study conclude that ELETP doses of 100mg/kgBB produce the largest muscle weight, while the largest muscle thickness is found at a dose of 200mg/kgBB.