CORRELATION BETWEEN NT-PROBNP LEVELS AND RIGHT VENTRICULAR FUNCTION IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION

Abstract

Maladaptive pulmonary arterial hypertension (HAP) can cause changes in function in the right ventricle (VKa) due to failure to compensate for the increase in afterload over a long period of time. Functional changes in VKa can be assessed using echocardiography parameters and also biomarkers, one of which is NT-proBNP. This study aims to determine the echocardiography parameters that correlate with the NT-proBNP levels of HAP patients so that they can assess VKa function in HAP patients and become an alternative  to cardiac magnetic resonance (CMR) examination as the gold standard that assesses VKa function. This study is a cross-sectional analytical research  with a sample of 30 patients diagnosed with HAP. The data obtained was then analyzed using the Spearman test. The results of this study showed a moderate positive correlation between echocardiography parameters and NT-proBNP levels whose values were RVEF (r=0.372 and p=0.043), TAPSE (r=0.371 and p=0.044), FAC (r=0.377 and p=0.040) and S' (r=0.370 and p=0.044), respectively. The conclusion of this study is that echocardiography examination with RVEF, TAPSE, FAC, and S' parameters has a moderate correlation relationship with NT-proBNP levels so that these 4 parameters can be used as alternative CMR in assessing VKa function.