PERAN FOSFOMYCIN PADA INFEKSI ENTEROBACTERALES PENGHASIL ENZIM ESBL

Abstract

Background : Enterobacterales is common cause of many type of infection, and for Enterobacterales ESBL producer, there are limited choice of antibiotic. Fosfomycin can be used as an alternatve especially when no other option available or when other antibiotic are less effective.

Method : All the sample in this study are collected form microbiology laboratory’s culture result during 18 months period and collect sensitivity for fosfomycin, ceftriaxone, cefotaxime, and carbapenem group. Fosfomycin sensitivity are presented by each species, for both ESBL and non ESBL producer group. ESBL producer bacteria based on resistant for ceftriaxone dan cefotaxime, while carbapenemase predicted by resistant against carbapenem group.

Result : Most sample collected are urine, followed by pus and sputum. Bacteria found in this study are dominated bu E. coli and Klebsiella sp. Both bacteria are dominated by ESBL producer. Fosfomycin sensitivity from this study are high except for Klebsiella sp ESBL group and Morganella morganii.

Conclusion : Fosfomycin can be used as an consideration for choosing empiric therapy although in area with high prevalence of ESBL producer bacteria. However, it is essential to consider the recommended therapeutic doses for various types of infections