THE RELATIONSHIP BETWEEN ASPARTATE AMINOTRANSFERASE (AST) AND ALANINE AMINOTRANSFERASE (ALT) WITH DISEASE SEVERITY IN COVID-19 INPATIENTS AT UDAYANA UNIVERSITY HOSPITAL FROM JANUARY 2020 TO DECEMBER 2021

Abstrak

The COVID-19 pandemic had a significant impact on global health. In addition to its high transmission rate, the clinical presentation of the disease varied, ranging from asymptomatic to critical cases. Previous studies found differences in laboratory results between critical and non-critical patients. One of these laboratory results was Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT). However, the relationship between AST and ALT with the disease severity in COVID-19 patients remained unclear. This study aimed to determine the relationship between AST and ALT with the disease severity in COVID-19 patients at Udayana University Hospital. This study used a cross-sectional approach involving 126 COVID-19 patients who were hospitalized at Udayana University Hospital. Data were collected through consecutive sampling from the medical records of COVID-19 patients from January 2020 to December 2021. Among the 126 COVID-19 patients studied, 64 were critical patients and 62 were non-critical patients. The median (min-max) age of critical patients was 59.5 years (18-76), while non-critical patients had a median age of 45.5 years (20-70). Laboratory data showed that 90.6% of critical COVID-19 patients had elevated AST levels and 64.1% had elevated ALT levels. The results of multivariate logistic regression analysis indicated a significant relationship between AST (PR: 3.929, 95% CI: 1.177-13.117) and ALT (PR: 2.881, 95% CI: 1.053-7.883) levels with the disease severity in COVID-19 patients. There was a significant relationship between AST and ALT levels with disease severity in COVID-19 patients at Udayana University Hospital.